Rod-cone signal interference in the retina shapes perception in primates

Linking the activity of neurons, circuits and synapses to human behavior is a fundamental goal neuroscience. Meeting this challenging, in part because behavior, particularly perception, often masks complexity underlying neural circuits, significant behavioral differences between primates animals like mice flies which genetic manipulations are relatively common. Here we relate circuit-level processing rod cone signals non-human primate retina known break normal seamlessness vision – surprising inability see high contrast flickering lights under specific conditions. We use electrophysiological recordings perceptual experiments identify key mechanisms that shape retinal integration rod- cone-generated signals. then incorporate these mechanistic insights into predicti\ve model accurately captures cancellation cone-mediated responses can explain insensitivity flicker.